Fig. 1 | Bone Research

Fig. 1

From: Runx1 is a key regulator of articular cartilage homeostasis by orchestrating YAP, TGFβ, and Wnt signaling in articular cartilage formation and osteoarthritis

Fig. 1The alternative text for this image may have been generated using AI.

Loss of Runx1 in chondrocytes exacerbated articular cartilage damage after DMM surgery. a Western blot of knee joints from 4.5-month-old Runx1f/f (F/F) and Runx1f/f Col2α1-Cre (F/F/Δ) mice. b Safranin O (SO) staining for hip joint. c Anti-Runx1 immunohistochemistry (IHC) staining of the hip joint of 3- and 4-month-old mice. d, e Safranin O (SO) staining of the knee joint of 3-month-old mice after (d) sham and (e) DMM surgery. f Knee joint and hip joint OARSI scores of (d and e). The results are presented as the mean ± SD, n = 3, *P < 0.05, **P < 0.01

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