Fig. 3 | Bone Research

Fig. 3

From: Neutralization of excessive levels of active TGF-β1 reduces MSC recruitment and differentiation to mitigate peritendinous adhesion

Fig. 3

M1 monocyte/macrophage levels are increased in mouse PAF tissues. Masson staining (a) and quantitative analysis of the space between the tendon and surrounding tissues (b) at days 14, 21 and 28 after tendon injury. Histological adhesion scores (c) and H&E staining (d) of normal tissues around tendons and PAF tissues on postoperative Days 1, 3, 7, 14, 21, and 28. Yellow arrowheads indicate the space between the tendon and surrounding tissues. Black arrowheads indicate the space occupied by adhesion tissues. Scale bar, 1 mm. Immunofluorescent staining of CD68+ (red) iNOS+ (green) cells (e) and quantitative analysis of CD68+ iNOS+ cells (f) per PAF tissue area (mm2). White arrowheads indicate the space between the tendon and surrounding tissues. Yellow arrowheads indicate the space occupied by adhesion tissues. Scale bar, 400 μm. * indicates P < 0.05. B, bone; D, day; M, muscle; R, repaired site; ROM, range of motion; T, tendon

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