Fig. 2 | Bone Research

Fig. 2

From: Fragile X Messenger Ribonucleoprotein 1 (FMR1), a novel inhibitor of osteoblast/osteocyte differentiation, regulates bone formation, mass, and strength in young and aged male and female mice

Fig. 2

Sex and age dependent effect of FMR1 deletion in cortical bone geometry of the femoral mid-diaphysis. µCT analyses were performed at the femoral mid-diaphysis at 2 (a) and 9 (b) months of age in male and female wild type (FMR1y/+ and FMR1+/+) and deficient (FMR1y/− and FMR1+/− and FMR1−/−) mice. Data are presented as minimum to maximum box and whiskers, with box boundaries indicating 25th to 75th percentile and horizontal lines, the median, and each dot corresponding to an individual sample. *P < 0.05 vs. FMR1y/+ mice for males by student’s t-test and vs. FMR1+/+ by one way ANOVA for females. Detailed statistical analyses are included in Table S1 (males) and S2 (females). Numbers above the graphs indicate sample size for each measurement. BA/TA bone area/tissue area, Ct.Th cortical thickness, Ps.Pm periosteal perimeter

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