Fig. 3 | Bone Research

Fig. 3

From: Fragile X Messenger Ribonucleoprotein 1 (FMR1), a novel inhibitor of osteoblast/osteocyte differentiation, regulates bone formation, mass, and strength in young and aged male and female mice

Fig. 3

FMR1 gene deletion results in increased cancellous bone mass in the distal femur in female but not male mice at 2 and 9 months of age. Structural parameters and volumetric bone mineral density were measured by µCT in 2- (a) and 9- (b) month-old mice. Data are presented as minimum to maximum box and whiskers, with box boundaries indicating 25th to 75th percentile and horizontal lines, the median, and each dot corresponding to an individual sample. *P < 0.05 vs. FMR1y/+ mice for males by student’s t-test and vs. FMR1+/+ by one way ANOVA for females. Detailed statistical analyses are included in Table S1 (males) and S2 (females). Numbers above the graphs indicate sample size for each measurement. BV/TV bone volume/tissue volume, TbTh trabecular thickness, TbN trabecular number, TbSp trabecular separation, vBMD volumetric bone mineral density

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