Table 1 Biomechanical properties of femoral cortical bone assessed by 3-point bending

From: Fragile X Messenger Ribonucleoprotein 1 (FMR1), a novel inhibitor of osteoblast/osteocyte differentiation, regulates bone formation, mass, and strength in young and aged male and female mice

Age

Parameter

MALES

FEMALES

FMR1y/+

FMR1y/−

FMR1y/−/FMR1y/+ (fold change)

FMR1+/+

FMR1+/−

FMR1−/−

FMR1−/−/FMR1+/+ (fold change)

2-month-old

Yield Force /N

14.48 ± 1.94

15.58 ± 1.96

1.1

16.07 ± 3.45

17.38 ± 2.54

16.73 ± 3.58

1.0

Ultimate Force /N

19.83 ± 1.78

21.60 ± 1.12

1.1

19.89 ± 2.76

21.59 ± 1.94

21.25 ± 2.42

1.1

Stiffness /(N·mm−1)

119.03 ± 14.52

131.75 ± 10.60

1.1

132.81 ± 17.49

145.89 ± 20.36

137.96 ± 17.29

1.0

Work to Yield /mJ

1.06 ± 0.18

1.11 ± 0.21

1.0

1.17 ± 0.37

1.24 ± 0.15

1.27 ± 0.41

1.1

Post-yield Work /mJ

6.56 ± 1.82

10.74 ± 4.04*

1.6

5.49 ± 1.70

7.10 ± 1.89

8.40 ± 2.21&

1.5

Total Work /mJ

7.63 ± 1.91

11.85 ± 3.92*

1.6

7.04 ± 1.76

8.34 ± 1.90

9.67 ± 2.18*

1.4

Yield Stress /MPa

122.32 ± 17.77

121.27 ± 23.32

1.0

141.33 ± 24.53

136.07 ± 21.82

137.54 ± 21.95

1.0

Ultimate Stress /MPa

167.32 ± 15.04

167.57 ± 19.55

1.0

175.19 ± 16.67

169.20 ± 20.28

175.65 ± 11.10

1.0

Modulus /GPa

6.07 ± 0.87

5.97 ± 1.04

1.0

7.08 ± 0.88

6.58 ± 1.61

6.99 ± 0.65

1.0

Resilience /MPa

1.49 ± 0.27

1.48 ± 0.34

1.0

1.70 ± 0.48

1.71 ± 0.16

1.71 ± 0.50

1.0

Toughness /MPa

10.73 ± 3.00

15.68 ± 4.94*

1.5

10.40 ± 3.06

11.50 ± 2.42

13.24 ± 3.59

1.3

9-month-old

Yield Force /N

16.13 ± 2.43

17.15 ± 3.34

1.0

17.58 ± 3.56

18.60 ± 2.40

20.32 ± 2.74

1.2

Ultimate Force /N

24.87 ± 3.98

26.91 ± 4.57

1.0

26.28 ± 3.26

25.71 ± 3.24

30.46 ± 4.13*

1.2

Stiffness /(N·mm−1)

139.76 ± 20.33

143.02 ± 27.30

1.0

154.53 ± 25.42

155.59 ± 16.89

180.47 ± 21.22*

1.2

Work to Yield /mJ

1.16 ± 0.24

1.26 ± 0.34

1.0

1.22 ± 0.34

1.37 ± 0.30

1.43 ± 0.28

1.2

Post-yield Work /mJ

4.93 ± 2.29

5.71 ± 2.29

1.1

3.69 ± 1.05

4.05 ± 1.84

6.05 ± 2.27*

1.6

Total Work /mJ

6.09 ± 2.32

6.97 ± 2.28

1.1

4.91 ± 1.13

5.42 ± 1.63

7.48 ± 2.16*

1.5

Yield Stress /MPa

117.19 ± 19.90

118.24 ± 28.61

1.0

110.70 ± 44.64

120.44 ± 21.11

121.36 ± 14.13

1.1

Ultimate Stress /MPa

179.05 ± 19.08

184.03 ± 32.90

1.0

158.61 ± 44.32

165.91 ± 23.45

181.69 ± 19.05

1.1

Modulus /GPa

6.44 ± 1.08

6.17 ± 1.58

0.9

5.63 ± 2.52

6.38 ± 1.14

6.70 ± 0.90

1.2

Resilience /MPa

1.33 ± 0.3

1.38 ± 0.39

1.0

1.32 ± 0.47

1.41 ± 0.36

1.38 ± 0.24

1.0

Toughness /MPa

6.85 ± 2.22

7.65 ± 2.61

1.1

5.16 ± 1.30

5.49 ± 1.53

7.24 ± 2.10*

1.4

  1. males:
  2. * = FMR1y/− versus FMR1y/+ by two-tailed Student’s t-test
  3. females:
  4. * = versus FMR1+/+ by one way ANOVA (Multiple comparisons versus Wild Type Group, Holm-Sidak Method)
  5. & = versus FMR1+/+ by one way ANOVA on RANKS (Multiple comparisons versus Wild Type Group - Dunn’s Method)
  6. Detailed statistical analyses are included in Table S5 (males) and S6 (females)
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