Fig. 10 | Bone Research

Fig. 10

From: CUL4B orchestrates mesenchymal stem cell commitment by epigenetically repressing KLF4 and C/EBPδ

Fig. 10

A model by which CUL4B regulates MSC fate commitment. Left, high levels of CUL4B in BMSCs of young mice could repress the transcription of Klf4 and cebpd and sustain osteogenic rather than adipogenic differentiation. Right, loss of CUL4B in BMSCs of MKO mice or decreased expression of CUL4B in BMSCs of old mice leads to increased expression of Klf4 and cebpd and promotes adipogenic differentiation at the expense of osteogenic differentiation

Back to article page