Fig. 1 | Bone Research

Fig. 1

From: Inhibiting WNT secretion reduces high bone mass caused by Sost loss-of-function or gain-of-function mutations in Lrp5

Fig. 1The alternative text for this image may have been generated using AI.

Sost treatment schematic and in vivo femoral and tibial pQCT measurements. a Schematic diagram of the experimental design. Longitudinal pQCT measurements of distal femur and proximal tibia metaphysis in 3-month-old female wild-type (WT) and Sost KO mice treated with vehicle or GNF-6231 daily for 40 days. The parameters measured include (b, c) total cross-sectional BMC (d, e) total cross-sectional BMD (f, g) cancellous BMD, and (h, i) cross-sectional cortical thickness. For all graphs, the means of each group are indicated by the shape, upper and lower lines represent standard deviations, and *P < 0.05. A minimum of six animals per genotype per condition were analyzed (see Table 1)

Back to article page