Table 2 Number of Lrp5 animals analyzed per genotype and treatment condition

From: Inhibiting WNT secretion reduces high bone mass caused by Sost loss-of-function or gain-of-function mutations in Lrp5

Analysis

Vehicle treatment

LGK974 treatment

A214V +/+ female

A/+ female

A214V +/+ male

A/+ male

G17V +/+ female

G/+ female

G17V +/+ male

G/+

male

A214V +/+ female

A/+ female

A214V +/+ male

A/+ male

G17V +/+ female

G/+ female

G17V +/+ male

G/+

male

DXA and µCT

6

6

5

5

5

5

5

5

5

6

5

6

5

5

5

6

Dynamic histomorp-hometry

5

4

3

5

4

5

4

5

4

4

4

4

4

3

3

3

Static histomorp-hometry

5

5

4

3

3

5

3

4

5

5

5

5

5

4

5

5

TRAP

  

5

5

  

2

4

  

5

5

  

3

3