Fig. 5 | Bone Research

Fig. 5

From: Phylobone: a comprehensive database of bone extracellular matrix proteins in human and model organisms

Fig. 5

Schematic representation of the state of the art in bone formation and remodeling mediated by extracellular matrix (ECM) proteins. a Simplified representation of processes involving osteocytes, osteoblasts, and osteoclast formation in the bone. ECM proteins can modulate them via activation or inhibition through signaling pathways. These mechanisms allow bone homeostasis to be controlled. b Percentage of proteins with putative structural or regulatory roles in the bone ECM based on annotations in the UniProt database.16

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