Table 2 Drugs that interact with more than one protein of the bone extracellular matrix (ECM)

From: Phylobone: a comprehensive database of bone extracellular matrix proteins in human and model organisms

Drug

Related proteins

Drug efficacy

Batimastat

P08253, P14780

Antineoplastic, Matrix metalloproteinase inhibitor

Cipemastat, Trocade

P14780, P45452

Antirheumatic, Cartilage protectant, Matrix metalloproteinase inhibitor

Ilomastat

P08253, P14780

Antineoplastic, Matrix metalloproteinase inhibitor

Marimastat

P08253, P14780

Antineoplastic, Matrix metalloproteinase inhibitor

Rebimastat

P08253, P14780

Antineoplastic, Matrix metalloproteinase inhibitor

Tanomastat

P08253, P14780

Antineoplastic, Matrix metalloproteinase inhibitor

Volociximab

P05556, P08648

Aging-related macular degeneration therapeutic agent, Antineoplastic, Angiogenesis inhibitor, Anti-alpha5beta1 integrin antibody

Fresolimumab

P10600, P61812

Immunomodulator, Anti-transforming growth factor beta antibody

Emicizumab, Hemlibra

P00740, P00742

Bleeding suppressant, Factor VIII replacement

Prinomastat

P08253, P14780, P45452

Antineoplastic, Angiogenesis inhibitor, Matrix metalloproteinase inhibitor

  1. There are 114 drugs that interact with at least 1 bone ECM protein (104 drugs interact with 1 protein, 9 drugs interact with 2 proteins, and 1 drug interacts with 3 proteins). The complete matrix of drug and protein interactions is available in Table S5
  2. P08253: 72 kDa type IV collagenase; P14780: Matrix metalloproteinase-9; P45452: Collagenase 3; P05556: Integrin beta-1; P08648 Integrin alpha-5; P10600: Transforming growth factor beta-3 proprotein; P61812: Transforming growth factor beta-2 proprotein; P00740: Coagulation factor IX; P00742: Coagulation factor X
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