Fig. 5 | Bone Research

Fig. 5

From: Skeletal interoception in osteoarthritis

Fig. 5

Two PGE2-mediated mechanisms of OA pain. During aberrant subchondral bone remodeling, OBs produced PGE2 binds to EP4 receptors on CGRP+ sensory nerves, sensitizing sensitize DRG neurons by modifying the voltage-gated sodium channel Nav1.8. PGE2 also stimulates OCs through EP4 receptors. Activated OCs release netrin1 to activated OCs release netrin1, which binds to the DCC receptors on sensory neurons, promoting the innervation of CGRP+ sensory nerves in the subchondral bone. OB osteoblast, PGE2 prostaglandin E2, EP prostaglandin E, CGRP calcitonin-gene-related peptide, DRG dorsal root ganglia, OC osteoclast, DCC deleted in colorectal cancer

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