Fig. 5 | Bone Research

Fig. 5

From: Pharmacologic or genetic targeting of peripheral nerves prevents peri-articular traumatic heterotopic ossification

Fig. 5

Bupivacaine lipid nanoparticles inhibit hip associated HO by radiology. a Schematic diagram of the experiment: Scx-eGFP mice received local injections of bupivacaine lipid nanoparticles (Bup-LNP) and PBS control 24 h before surgery and every 3 d after acetabular reaming. Mice were analyzed 3 weeks post-operative. b Representative roentgenography (XR) and microcomputed tomography (µCT) images of Bup-LNP and control treated animals. Yellow arrows and yellow colorization highlight HO areas. c Grading of HO according to a modified Brooker classification. d Quantitative μCT analysis of total HO, including bone surface (BS) and bone volume (BV). e Quantitative μCT analysis of the acetabulum associated HO. f Quantitative μCT analysis of femur associated HO. Scale bars: 1 mm. Data presented as mean ± 1 SD. Dots in scatterplots represent an individual animal. Unpaired two-tailed Student’s t test was used for a two-group comparison. *P < 0.05, **P < 0.01

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