Fig. 3 | Bone Research

Fig. 3

From: Skeletal progenitor LRP1 deficiency causes severe and persistent skeletal defects with Wnt pathway dysregulation

Fig. 3

LRP1 deficiency in skeletal progenitors results in dwarfism, impaired mobility and fore/hind limb malformation. a Mouse weight measurement from 3-14 weeks after birth. Closed (male) and open (female) black circles (WT), black triangles (cHet; Lrp1flox/wt/Prrx1Cre heterozygote conditional KO), and red squares (cKO; Lrp1flox/flox/Prrx1Cre homozygote conditional KO) represent individual mice. b Total distance and average speed of WT and cKO mice. Locomotor activity of 6-week-old mice measured by the continuous automated home-cage monitoring system for 4 weeks. Circles represent individual mice and bars show the mean ± SD. **P < 0.01 by 2-tailed Student’s t test. c Whole-mount skeletal staining of 14-week-old mice with Alcian blue and Alizarin red. d Photographs of 8-week-old WT and the cKO hind paws. e Photographs of 8-14-week-old WT and the cKO fore paws. f Table showing the frequencies of the identified phenotypes

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