Fig. 7 | Bone Research

Fig. 7

From: Skeletal progenitor LRP1 deficiency causes severe and persistent skeletal defects with Wnt pathway dysregulation

Fig. 7

LRP1 partially colocalises with Wnt5a and its deficiency alters abundance and distribution of Wnt5a in the developing limbs. Representative images of confocal microscopy analysis for Wnt5a and LRP1 (a and b), and total (c and e) and phosphorylated Vangl2 (d and f) in E13.5 (a, c and d) or E16.5 (b, e and f) hind limb sections of WT and Lrp1flox/flox/Prrx1Cre (cKO) mice (n = 3). Wnt5a, LRP1, Vangl2, phospho-Vangl2 and nucleus were visualised as described under “Materials and Methods”. Regions delineated by the white squares have been magnified in the top right of each panel. PF proliferative flattened chondrocytes; PC perichondrium. Scale bar, 50 µm

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