Fig. 5
From: Matrix stiffness regulates nucleus pulposus cell glycolysis by MRTF-A-dependent mechanotransduction
MRTF-A overexpression promotes the IVDD progression. a Schematic diagram of the process of rats receiving AAV-MRTF-A injections (black arrows indicate representative positive cells). b, c The MRI images of rat discs and Pfirrmann score quantification (0–8). d, e CT three-dimensional images of rat intervertebral discs and disc height index quantification. f The histological staining images of intervertebral discs at 4 and 8 weeks after treatment. g, h The IHC images of intervertebral discs at 8 weeks after treatment and its quantitative analyses. Black scale bar = 200 μm and white scale bar = 1 000 μm. *P < 0.05, **P < 0.01, ***P < 0.001
