Fig. 4
From: Porcupine inhibition is a promising pharmacological treatment for severe sclerosteosis pathologies
LGK974 treatment decreases bone morphometric parameters in the Sost-/- skull. a Effect of LGK974 on the cortical bone volume (BV) and (b) bone volume fraction (BV/TV) of Sost-/- whole skulls (male and female; **P ≤ 0.01). c Representative images from a male Sost-/- mouse to highlight the analysed region between the anterior lambdoid and coronal sutures (white rectangle). 2D analysis was done from anterior to posterior (white arrow) of the selected region. d Bone and tissue area (B.Ar and T.Ar) and thickness of the whole parietal bone section of male treated and untreated Sost-/- mice. e The same parameters as 'd', but for females. For all graphs, means of each group are indicated by the solid line, SEM by coloured area. Blue and red represent vehicle and LGK974 treated groups, respectively. Heatmap: dark blue: P ≤ 1; green: P ≤ 0.05; light blue: P ≤ 0.01. Group sizes were n = 5 treated females, n = 6 non-treated females, n = 4 treated males and n = 5 non-treated males
