Fig. 5

Histological results of animal experiments. a Representative H&E staining images of IVD in Sham, PBS, OKS, M-Exo and OKS@M-Exo groups at weeks 4 and 8 after treatment. Scale bar, 500 μm. Representative IHC analysis of rat IVD sections to assess ACAN (b), MMP13 (c), P21 (d) in Sham, PBS, OKS, M-Exo and OKS@M-Exo groups at weeks 4 and 8 after treatment. Scale bar, 500 μm