Fig. 2
From: PTPN11 in cartilage development, adult homeostasis, and diseases
Mutations in SHP2 and its signaling partners associated with human METCDS and RASopathies. a Diagrams depicting METCDS variants identified in the functional domains of SHP2. Additional information can be found at https://www.uniprot.org/uniprotkb/Q06124/entry#disease_variants. b Schematic model of the RAS pathway, with protein components colored according to the METCDS and RASopathies caused by mutations in their genes
