Fig. 6
From: PTPN11 in cartilage development, adult homeostasis, and diseases
Diagrams depicting mechanism(s) by which SHP2 may regulate SOX9 and β-catenin protein stability through modifying its phosphorylation, SUMOylation, and ubiquitin-mediated proteasomal degradation in response to Wnt, IL-1β, and cAMP-evoked signlaing pathway activation in chondrocytes. MG132: proteosome inhibitor
