Fig. 5 | Bone Research

Fig. 5

From: Galactose-modified small molecule modulator targets RORα to enhance circadian rhythm and alleviate periodontitis-associated alveolar bone loss

Fig. 5

Gala-SR enhances the rhythm amplitude to improve circadian rhythms in vivo. a Actograms illustrating the effect of DMSO, SR1078 and Gala-SR on circadian behavior in C57 mice, SR1078 and Gala-SR (10 mg/kg) were intraperitoneally injected at ZT11 (n = 4); b Amplitude [*represents the comparison with DMSO (DD) and # represents the comparison with SR1078(DD), *P < 0.05, #P < 0.05]; c Daily total activity of mice; d Live images of PER2::LUC mice that were intraperitoneally injected with SR1078, Gala-SR or DMSO at ZT0; e The mRNA expression of clock genes in liver tissues collected from jet lag mice treated with Gala-SR, SR1078, and DMSO at different time points (n = 4); f The mRNA expression of RORα downstream target gene in mice liver tissues at different time points (n = 4). (* represents the comparison with DMSO and #represents the comparison with SR1078, *P < 0.05, #P < 0.05, n = 4)

Back to article page