Fig. 6 | Bone Research

Fig. 6

From: Nucleic acid aptamers in orthopedic diseases: promising therapeutic agents for bone disorders

Fig. 6The alternative text for this image may have been generated using AI.

The mechanism of nucleic acid aptamers on chondrocytes in the pathological process of OA. a Schematic representation of the synthesis of tgg2-PEG2000-PAMAM6.0-Cy5.5. b Differentiated diffusion models of cationic nanocarriers binding to the negatively charged extracellular matrix (ECM) of chondrocytes via electrostatic interactions, followed by delivery into chondrocytes in normal and OA cartilage. c Modulation of the SIRT1/IL-6/STAT3 signaling pathway by miR-141/200c. Reproduced form ref. 410 with permission from Elsevier, copyright 2021

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