Fig. 2 | Bone Research

Fig. 2

From: SMN deficiency inhibits endochondral ossification via promoting TRAF6-induced ubiquitination degradation of YBX1 in spinal muscular atrophy

Fig. 2

SMN deficiency induces abnormal growth plate anatomy. a–c HE staining of growth plates from SMA and Het mice at P4, P7, or after ASO treatment (a). Histograms show ratio of HZ area (b) and HZ height (c) in growth plates (n = 6 per group). P-value was derived from two-tailed unpaired Student’s t test. d–f SF staining of hypertrophic chondrocytes in HZ of SMA and Het mice at P4, P7, or after ASO treatment (d). Histograms show cell size (e) and cell density (f) of hypertrophic chondrocytes in HZ (n = 6 per group). P-value was derived from two-tailed unpaired Student’s t test. g–i VK staining of HZ and metaphysis from SMA and Het mice at P4, P7, or after ASO treatment (g). Histograms show ratio of calcification in HZ (h) and metaphysis (i) (n = 6 per group). P-value was derived from two-tailed unpaired Student’s t test. Data are presented as the mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001

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