Table 2 Incidence rates and hazard ratios for all-cause dementia, AD, and VD for the osteoporosis patients and control groups
From: Osteoporosis and risk of dementia among older adults: a population‑based cohort study
Outcome | N | No. of events | Person-years | IR (95% CI), per 1 000 person-years | Model 1 | Model 2 | Model 3 | |||
|---|---|---|---|---|---|---|---|---|---|---|
HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | |||||
Full cohort analysis | ||||||||||
All-cause dementia | ||||||||||
Control group | 166 545 | 1 185 | 481 609.0 | 2.46 (2.32–2.60) | ref | ref | ref | |||
Osteoporosis group | 9 605 | 182 | 23 813.9 | 7.64 (6.57–8.84) | 2.18 (1.85–2.56) | <0.001 | 2.12 (1.80–2.49) | <0.001 | 1.80 (1.53–2.12) | <0.001 |
AD | ||||||||||
Control group | 166 545 | 543 | 482 491.3 | 1.13 (1.03–1.22) | ref | ref | ref | |||
Osteoporosis group | 9 605 | 74 | 23 964.7 | 3.09 (2.42–3.88) | 1.89 (1.47–2.43) | <0.001 | 1.84 (1.43–2.36) | <0.001 | 1.55 (1.20–2.00) | 0.001 |
VD | ||||||||||
Control group | 166 545 | 252 | 482 825.2 | 0.52 (0.46–0.59) | ref | ref | ref | |||
Osteoporosis group | 9 605 | 46 | 23 992.5 | 1.92 (1.40–2.56) | 2.93 (2.11–4.08) | <0.001 | 2.89 (2.08–4.01) | <0.001 | 2.13 (1.52–2.98) | <0.001 |
Matched cohort analysis | ||||||||||
All-cause dementia | ||||||||||
Control group | 43 913 | 526 | 130 015.3 | 4.05 (3.71–4.41) | ref | ref | ref | |||
Osteoporosis group | 9 530 | 175 | 23 643.4 | 7.40 (6.35–8.58) | 1.83 (1.53–2.19) | <0.001 | 1.81 (1.51–2.17) | <0.001 | 1.79 (1.49–2.15) | <0.001 |
AD | ||||||||||
Control group | 43 913 | 250 | 130 401.1 | 1.92 (1.69–2.17) | ref | ref | ref | |||
Osteoporosis group | 9 530 | 72 | 23 785.3 | 3.03 (2.37–3.81) | 1.63 (1.25–2.14) | <0.001 | 1.61 (1.23–2.12) | 0.001 | 1.59 (1.21–2.09) | 0.001 |
VD | ||||||||||
Control group | 43 913 | 118 | 130 558.7 | 0.90 (0.75–1.08) | ref | ref | ref | |||
Osteoporosis group | 9 530 | 45 | 23 812.3 | 1.89 (1.38–2.53) | 2.01 (1.41–2.86) | <0.001 | 1.99 (1.39–2.83) | <0.001 | 1.94 (1.36–2.77) | <0.001 |
