Table 1 Electrical characteristics of conductive hydrogels in promoting bone healing

From: Electric field stimulation-responsive hydrogels for bone regeneration: from mechanisms to applications

Matrix

Conducting materials

Crosslink

Micro-structure

Diameter

Conductivity

Ref.

MA

PEDOT:PSS, MgtiO3

noncovalent bond

granular

-

C@MA:0.44 ± 0.03 mS/cm

CP@MA:1.29 ± 0.08 mS/cm

CPM@MA:1.52 ± 0.09 mS/cm

175

GelMA

PPy, Fe3+

noncovalent bond, covalent bond

porous meshwork

(11.23 ± 1.05) μm (GelMA-PPy-Fe)

GelMA-PPy-Fe:9.6 ± 1.3 mS/cm

153

GelMA

Mg2+, BP nanosheets

covalent bond

granular

250–300 μm

0.10 S/m

180

GelMA

BP nanosheets

covalent bond

granular

d = 200 μm

0.22 S/m

213

GelMA

PPyNWs

covalent bond

porous meshwork

8 ± 4.1 μm

0.263 ±0.020 S/m (GelMA@4PPy)

214

Carboxymethyl chitosan

CNT

covalent bond

porous meshwork

50–80 μm

-

181

PVA, CH, SA

MWCNT-COOH, GNP

noncovalent bond

porous meshwork

12.1 ± 26.6 μm(PVA/CH/SA)

13.9 ± 30.0 μm(+CNT)

17.0 ± 35.3 μm (+CNT + GNP)

(1.8 ± 0.02) × 10−5 S/m(PVA/CH/SA)

(5.7 ± 0.24) × 10−2 S/m(PVA/CH/SA-CNT)

(6.3 ± 0.05) × 10−3 S/m(PVA/CH/SA-GNP)

147

PVA

N3+ ion

noncovalent bond

platy

-

1.59 μS/cm (1e15)

1.91 μS/cm (5e15)

2 μS/cm (1e16)

179

Acrylamide, gelatin, deacetylated chitosan

Mo2Ti2C3, MXene

covalent bond

porous meshwork

-

50 mS/cm (20 μg/mL MXene)

55 mS/cm (40 μg/mL MXene)

60 mS/cm (80 μg/mL MXene)

235

PAA

GO

covalent bond

porous meshwork

2–10

17 × 10−4 S/cm (0.2% GO-PAA)

25 × 10−4 S/cm (0.4% GO-PAA)

33 × 10−4 S/cm (0.6% GO-PAA)

236

Gel

PEDOT: PSS

covalent bond

porous meshwork

50–250 μm (0.3% PEDOT:PSS)

70–150 μm (0.1% PEDOT:PSS)

170 μS/m (0.3% PEDOT:PSS)

100 μS/m (0.1% PEDOT:PSS)

237

GelMA

MWCNT

covalent bond

spherical pellet

-

9.21 S/cm (70-30-5)

238,239

OPF gel

CNT-PEG-acrylate (CNT-pega), BP

covalent bond

tubular-like morphological features

-

0.008 S/m (CNTpega 16 mg/mL, BP 0.8 mg/mL)

 

GP, OP

PPy

covalent bond

porous meshwork

173.13 μm (G-OP)

295.96 μm (GP15-OP)

0.06 mS/m (G-OP)

2.14 ± mS/m (GP15-OP)

240

RSF

MXene

noncovalent bond, covalent bond

porous meshwork

-

4 × 10⁻⁴ S/cm (8 mg/mL MXene)

187

ECM, AlgMA

BP@PDA

covalent bond

porous meshwork

-

0.059 S/m

211

  1. MA methacrylated alginate, GelMA gelatin methacryloyl, BP black phosphorus, PVA polyvinyl alcohol, CH chitosan, SA sodium alginate, PAA polyacrylic acid, GO Graphene oxide, Gel gelatin, OPF oligo(poly(ethylene glycol) fumarate, CNT carbon nanotubes, PEG poly(ethylene glycol), RSF regenerated silk fibroin, CALM calmodulin, GP gelatin-graft-polypyrrole, OP oxidized pectin, AlgMA alginate methacryloyl