Abstract
Non-sugar sweeteners (NSSs) are low-calorie artificial alternatives to sugar, widely used in food, drinks, medicines and hygiene products. Their popularity has surged over recent decades, particularly for weight management and diabetes control. This paper examines the most commonly used NSSs in the United Kingdom, evaluating their chemical compositions and regulatory standards. Key findings reveal that NSSs may provide dental health benefits by reducing the risk of caries; however, their effects on metabolic health remain a topic of debate. While NSSs offer clear advantages for individuals seeking to limit sugar intake, research also points to possible long-term health implications, thus this paper highlights the importance of informed usage to minimise possible adverse effects, emphasising the need for balanced patient guidance on their consumption.
Key points
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Provides a review of the non-sugar sweeteners commonly used in the United Kingdom.
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Reviews the possible benefits of non-sugar sweeteners (such as caries prevention).
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Explores any negative effects of non-sugar sweeteners to better educate our patients.
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References
Weihrauch M R, Diehl V. Artificial sweeteners – do they bear a carcinogenic risk?. Ann Oncol 2004; 15: 1460–1465.
Farhat G, Dewison F, Stevenson L. Knowledge and perceptions of non-nutritive sweeteners within the UK adult population. Nutrients 2021; 13: 444.
Pepino M Y. Metabolic effects of non-nutritive sweeteners. Physiol Behav 2015; 152: 450–455.
Drewnowski A. Intense sweeteners and energy density of foods: implications for weight control. Eur J Clin Nutr 1999; 53: 757–763.
Miller P E, Perez V. Low-calorie sweeteners and body weight and composition: a meta-analysis of randomized controlled trials and prospective cohort studies. Am J Clin Nutr 2014; 100: 765–777.
Fowler S P, Williams K, Resendez R G, Hunt K J, Hazuda H P, Stern M P. Fuelling the obesity epidemic? Artificially sweetened beverage use and long-term weight gain. Obesity 2008; 16: 1894–1900.
Manavalan D, Shubrook C, Young C F. Consumption of non-nutritive sweeteners and risk for type 2 diabetes: what do we know, and not?. Curr Diabetes Rep 2021; 21: 53.
World Health Organization. Use of non-sugar sweeteners: WHO guideline. 2023. Available at https://www.who.int/publications/i/item/9789240073616 (accessed 1 January 2025).
Statista. UK Artificial Sweetener – United Kingdom. 2025. Available at https://www.statista.com/outlook/cmo/food/spreads-sweeteners/sweeteners/artificial-sweeteners/united-kingdom (accessed 1 January 2025).
Lohner S, Toews S I, Meerpohl J J. Health outcomes of non-nutritive sweeteners: analysis of the research landscape. Nutr J 2017; 16: 55.
Kalkhoff R K, Levin M E. The saccharin controversy. Diabetes Care 1978; 1: 211–222.
Food and Drug Administration. Sweetness intensity of sweeteners compared to tabletop sugar. Available at https://www.fda.gov/media/168345/download (accessed 1 January 2025).
Market Data Forecast. Global artificial sweetener market size. 2025. Available at https://www.marketdataforecast.com/market-reports/artificial-sweetener-market (accessed 1 August 2024).
The Association of UK Dieticians. Joint Position Statement on the Use of Low or No Calorie Sweeteners (LNCS). 2016.
Janssen P J, van Der Heijden C A. Aspartame: review of recent experimental and observational data. Toxicology 1988; 50: 1–26.
Suckling J, Morse S, Murphy R et al. Environmental life cycle assessment of production of the non-nutritive sweeteners aspartame (E951) and neotame (E961) from chemical processes: the SWEET project. J Cleaner Prod 2023; 424: 138854.
Mahmood A A, Al-Juboori S B. A review: saccharin discovery, synthesis, and applications. Ibn AL Haitham J For Pure Appl Sci 2020; 33: 43–61.
De Oliveira D N, de Menezes M, Catharino R R. Thermal degradation of sucralose: a combination of analytical methods to determine stability and chlorinated byproducts. Sci Rep 2015; 5: 9598.
Goyal S K, Samsher N, Goyal R. Stevia (Stevia rebaudiana) a bio-sweetener: a review. Int J Food Sci Nutr 2010; 61: 1–10.
Grembecka M. Sugar alcohols – their role in the modern world of sweeteners: a review. Eur Food Res Technol 2015; 241: 1–4.
World Health Organization. Aspartame hazard and risk assessment results released. 2023. Available at https://www.who.int/news/item/14-07-2023-aspartame-hazard-and-risk-assessment-results-released (accessed 1 May 2024).
World Health Organization. Sugars and dental caries. 2017. Available at https://www.who.int/news-room/fact-sheets/detail/sugars-and-dental-caries (accessed 1 April 2024).
Kazeminia M, Abdi A, Shohaimi S et al. Dental caries in primary and permanent teeth in children's worldwide, 1995 to 2019: a systematic review and meta-analysis. Head Face Med 2020; 16: 22.
O'Donnell K, Kearsley M W. Sweeteners and Sugar Alternatives in Food Technology. New Jersey: John Wiley & Sons, 2012.
Gupta P, Gupta N, Pawar A P, Birajdar S S, Natt A S, Singh H P. Role of sugar and sugar substitutes in dental caries: a review. Int Scholarly Res Notices 2013; 2013: 519421.
Deshpande A, Jadad A R. The impact of polyol-containing chewing gums on dental caries: a systematic review of original randomized controlled trials and observational studies. J Am Dent Assoc 2008; 139: 1602–1614.
Maguire A, Rugg-Gunn A J. Xylitol and caries prevention – is it a magic bullet? Br Dent J 2003; 194: 429–436.
Imfeld T. Chewing gum – facts and fiction: a review of gum-chewing and oral health. Crit Rev Oral Biol Med 1999; 10: 405–419.
Söderling E, Pienihäkkinen K. Effects of xylitol and erythritol consumption on mutans streptococci and the oral microbiota: a systematic review. Acta Odontol Scand 2020; 78: 599–608.
Dodds M W J. The oral health benefits of chewing gum. J Ir Dent Assoc 2012; 58: 253–261.
Qin P, Li Q, Zhao Y et al. Sugar and artificially sweetened beverages and risk of obesity, type 2 diabetes mellitus, hypertension, and all-cause mortality: a dose-response meta-analysis of prospective cohort studies. Eur J Epidemiol 2020; 35: 655–671.
Debras C, Deschasaux-Tanguy M, Chazelas E et al. Artificial sweeteners and risk of type 2 diabetes in the prospective NutriNet-Santé cohort. Diabetes Care 2023; 46: 1681–1690.
O'Connor L, Imamura F, Lentjes M A, Khaw K-T, Wareham N J, Forouhi N G. Prospective associations and population impact of sweet beverage intake and type 2 diabetes, and effects of substitutions with alternative beverages. Diabetologia 2015; 58: 1474–1483.
Pearlman M, Obert J, Casey L. The association between artificial sweeteners and obesity. Curr Gastroenterol Rep 2017; 19: 64.
Ebbeling C B, Feldman H A, Steltz S K, Quinn N L, Robinson L M, Ludwig D S. Effects of sugar-sweetened, artificially sweetened, and unsweetened beverages on cardiometabolic risk factors, body composition, and sweet taste preference: a randomized controlled trial. J Am Heart Assoc 2020; DOI: 10.1161/JAHA.119.015668.
Azad M B, Sharma A K, de Souza R J et al. Association between artificially sweetened beverage consumption during pregnancy and infant body mass index. JAMA Pediatr 2016; 170: 662–670.
Sylvetsky A C, Rother K I. Nonnutritive sweeteners in weight management and chronic disease: a review. Obesity 2018; 26: 635–640.
Jang H-J, Kokrashvili Z, Theodorakis M J et al. Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1. Proc Natl Acad Sci 2007; 104: 15069–15074.
Joseph P, Leong D, McKee M et al. Reducing the global burden of cardiovascular disease, part 1: the epidemiology and risk factors. Circ Res 2017; 121: 677–694.
Huang Y, Chen Z, Chen B et al. Dietary sugar consumption and health: umbrella review. BMJ 2023; DOI: 10.1136/bmj-2022-071609.
Welsh J A, Sharma A, Cunningham S A, Vos M B. Consumption of added sugars and indicators of cardiovascular disease risk among US adolescents. Circulation 2011; 123: 249–257.
Radenkovic S. Investigating the effects of artificial sweeteners. Nat Rev Endocrinol 2023; 19: 442.
Chazelas E, Debras C, Srour B et al. Sugary drinks, artificially sweetened beverages and cardiovascular disease in NutriNet-Santé cohort. J Am Coll Cardiol 2020; 76: 2175–2177.
Rios-Leyvraz M, Montez J. Health effects of the use of non-sugar sweeteners: a systematic review and meta-analysis. 2022. Available at https://www.who.int/publications/i/item/9789240046429 (accessed 1 January 2026).
Sun T, Yang J, Lei F et al. Artificial sweeteners and risk of incident cardiovascular disease and mortality: evidence from UK Biobank. Cardiovasc Diabetol 2024; 23: 233.
Suez J, Korem T, Zeevi D et al. Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature 2014; 514: 181–186.
Basson A R, Rodriguez-Palacios A, Cominelli F. Artificial sweeteners: history and new concepts on inflammation. Front Nutr 2021; 8: 746247.
Bian X, Tu P, Chi L, Gao B, Ru H, Lu K. Saccharin induced liver inflammation in mice by altering the gut microbiota and its metabolic functions. Food Chem Toxicol 2017; 107: 530–539.
Witkowski M, Nemet I, Alamri H et al. The artificial sweetener erythritol and cardiovascular event risk. Nat Med 2023; 29: 710–718.
Howe G R, Burch J D, Miller A B et al. Artificial sweeteners and human bladder cancer. Lancet 1977; 310: 578–581.
Wynder E L, Stellman S D. Artificial sweetener use and bladder cancer: a case-control study. Science 1980; 207: 1214–1216.
Capen C C, Dybing E, Rice J M, Wilbourn J D. Species Differences in Thyroid, Kidney and Urinary Bladder Carcinogenesis. Lyon: IARC Scientific Publications, 1999.
Soffritti M, Belpoggi F, Manservigi M et al. Aspartame administered in feed, beginning prenatally through life span, induces cancers of the liver and lung in male Swiss mice. Am J Ind Med 2010; 53: 1197–1206.
Debras C, Chazelas E, Srour B et al. Artificial sweeteners and cancer risk: Results from the NutriNet-Santé population-based cohort study. PLos Med 2022; DOI: 10.1371/journal.pmed.1003950.
Wise J. Aspartame is ‘possibly carcinogenic' but current recommended intake is safe, experts rule. BMJ 2023; 382: 1623.
Rycerz K, Jaworska-Adamu J E. Effects of aspartame metabolites on astrocytes and neurons. Folia Neuropathol 2013; 51: 10–17.
Lindseth G N, Coolahan S E, Petros T V, Lindseth P D. Neurobehavioral effects of aspartame consumption. Res Nurs Health 2014; 37: 185–193.
Miller B, Branscum P. Evaluating the association between artificial sweetener intake and indicators of stress and anxiety. Community Health Equity Res Policy 2023; 43: 339–342.
Choudhary A K, Lee Y Y. Neurophysiological symptoms and aspartame: what is the connection? Nutr Neurosci 2018; 21: 306–316.
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MC conceived the idea for the review. STA conducted the literature search and drafted the manuscript. MC and KP critically reviewed the manuscript for intellectual content, and all corrections were reviewed and revised by STA. All authors approved the final version of the manuscript.
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Aghababaie, S., Parker, K. & Chia, M. Non-sugar sweeteners – too sweet to be true?. Br Dent J 240, 107–111 (2026). https://doi.org/10.1038/s41415-025-9252-8
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DOI: https://doi.org/10.1038/s41415-025-9252-8


