Abstract
Obstructive sleep apnoea (OSA) is a common medical condition with significant morbidity and mortality, but frequently undiagnosed. Clinical signs and symptoms may be identified by general dental practitioners during routine dental examinations and patient history taking. This article explores the clinical characteristics, aetiology, and prevalence of OSA, and outlines when a referral should be considered, including the essential details to include in the referral. Additionally, it examines the current clinical pathway following referral, detailing the assessment and planning process for maxillomandibular advancement surgery (MMA). The discussion outlines the indications, benefits, and risks of MMA and compares it with alternative treatment options. The goal of this paper is to equip general dental practitioners with the knowledge and confidence to make informed referrals, assist in communicating both conservative and potential surgical treatment options to their patients, and provide a clear outline of what to expect following a referral for OSA in the UK.
Key points
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Highlights the high prevalence, aetiology, and common signs and clinical symptoms of obstructive sleep apnoea that may be identified by general dental practitioners.
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Provides an overview of the referral pathway from initial screening, onward referral for a sleep study to potential further management at tertiary care.
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Offers insight into the indications, mechanism, surgical planning, and postoperative care of maxillomandibular advancement surgery for obstructive sleep apnoea patients.
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References
Punjabi N M. The epidemiology of adult obstructive sleep apnea. Proc Am Thorac Soc 2008; 5: 136–143.
National Institute for Health and Care Excellence. Workplace health: long-term sickness absence and capability to work. 2021. Available at https://www.nice.org.uk/guidance/ng202/resources/resource-impact-report-pdf-9204442093 (accessed 18 August 2025).
Harvard Medical School. Sleep and health education program. 2023. Available at https://sleep.hms.harvard.edu/education-training/public-education/sleep-and-health-education-program/sleep-health-education-0 (accessed 18 August 2025).
Patil S P, Schneider H, Schwartz A R, Smith P L. Adult obstructive sleep apnea: pathophysiology and diagnosis. Chest 2007; 132: 325–337.
National Institute for Health and Care Excellence. Obstructive sleep apnoea/hypopnoea syndrome and obesity hypoventilation syndrome in over 16s (NG202). 2021. Available at https://www.nice.org.uk/guidance/ng202/resources/obstructive-sleep-apnoeahypopnoea-syndrome-and-obesity-hypoventilation-syndrome-in-over-16s-pdf-66143711375557 (accessed 18 August 2025).
Osman A M, Carter S G, Carberry J C, Eckert D J. Obstructive sleep apnea: current perspectives. Nat Sci Sleep 2018; 10: 21–34.
Boyd S B, Walters A S, Waite P, Harding S M, Song Y. Long-term effectiveness and safety of maxillomandibular advancement for treatment of obstructive sleep apnea. J Clin Sleep Med 2015; 11: 699–708.
Lye K W, Waite P D, Meara D, Wang D. Quality of life evaluation of maxillomandibular advancement surgery for treatment of obstructive sleep apnea. J Oral Maxillofac Surg 2008; 66: 968–972.
Budhiraja R, Parthasarathy S, Quan S F. Endothelial dysfunction in obstructive sleep apnea. J Clin Sleep Med 2007; 3: 409–415.
Dempsey J A, Veasey S C, Morgan B J, O'Donnell C P. Pathophysiology of sleep apnea. Physiol Rev 2010; 90: 47–112.
Jordan A S, McSharry D G, Malhotra A. Adult obstructive sleep apnoea. Lancet 2014; 383: 736–747.
Schwab J. Sex differences and sleep apnoea. Thorax 1999; 54: 284–285.
Yeghiazarians Y, Jneid H, Tietjens J R et al. Obstructive sleep apnea and cardiovascular disease: a scientific statement from the American heart association. Circulation 2021; 144: 56–67.
Kotecha B, De Vito A. Drug induced sleep endoscopy: its role in evaluation of the upper airway obstruction and patient selection for surgical and non-surgical treatment. J Thorac Dis 2018; 10: 40–47.
Shepard J W Jr Gefter W B, Guilleminault C et al. Evaluation of the upper airway in patients with obstructive sleep apnea. Sleep 1991; 14: 361–371.
Suratt P M, Mater R F, Wilhoit S C. Collapsibility of nasopharyngeal airway in obstructive sleep apnea. Am Rev Respir Dis 1985; 132: 967–971.
Riley R, Guilleminault C, Herran J, Powell N. Cephalometric analyses and flow volume loops in obstructive sleep apnea. Sleep 1983; 6: 303–311.
Jamieson A, Guilleminault C, Partinen M, Quera-Salva M A. Obstructive sleep apneic patients have cranio-mandibular abnormalities. Sleep 1986; 9: 469–477.
Suratt P M, Dee P, Atkinson R L, Armstrong P, Wilhoit S C. Fluoroscopic and computed tomographic features of the pharyngeal airway in obstructive sleep apnea. Am Rev Respir Dis 1983; 127: 487–492.
Stein M G, Gamsu G, de Geer G, Golden J A, Crumley R L, Webb W R. Cine CT in obstructive sleep apnea. Am J Roentgenol 1987; 148: 1069–1074.
Liistro G, Stanescu D, Dooms G, Rodenstein D, Veriter C. Head position modifies upper airway resistance in men. J Appl Physiol 1988; 64: 1285–1288.
UK Government. Excessive sleepiness and driving. 2024. Available at https://www.gov.uk/excessive-sleepiness-and-driving (accessed 18 August 2025).
Lv R, Liu X, Zhang Y et al. Pathophysiological mechanisms and therapeutic approaches in obstructive sleep apnea syndrome. Signal Transduct Target Ther 2023; 8: 218.
National Health Service. Self-help guidance. Available at https://www.uhbristol.nhs.uk/patients-and-visitors/your-hospitals/bristol-royal-infirmary/what-we-do/sleep-and-home-ventilation-unit/sleep-patients/self-help-guidance/ (Accessed 20 December 2024).
Ghadiri M, Grunstein R R. Clinical side effects of continuous positive airway pressure in patients with obstructive sleep apnoea. Respirology 2020; 25: 593–602.
Batool-Anwar S, Goodwin J L, Kushida C A et al. Impact of continuous positive airway pressure on quality of life in patients with obstructive sleep apnea. J Sleep Res 2016; 25: 731–738.
Spicuzza L, Caruso D, Di Maria G. Obstructive sleep apnoea syndrome and its management. Ther Adv Chronic Dis 2015; 6: 273–285.
Cao M T, Sternbach J M, Guilleminault C. Continuous positive airway pressure therapy in obstructive sleep apnea: benefits and alternatives. Expert Rev Respir Med 2017; 11: 259–272.
Strohl K P, Redline S. Nasal CPAP therapy, upper airway muscle activation, and obstructive sleep apnea. Am Rev Respir Dis 1986; 134: 555–558.
Parmenter D, Millar B J. How can general dental practitioners help in the management of sleep apnoea?. Br Dent J 2023; 234: 505–509.
Zaghi S, Holty J E, Certal V et al. Maxillomandibular advancement for treatment of obstructive sleep apnea: a meta-analysis. JAMA Otolaryngol Head Neck Surg 2016; 142: 58–66.
Vanderveken O M, Hoekema A. How to treat patients that do not tolerate continuous positive airway pressure. Breathe 2010; 7: 157–167.
Erickson K L, Bell W H, Goldsmith D H. Analytical model surgery. In Bell WH, Guerrero CA (ed) Distraction Osteogenesis of the Facial Skeleton. pp 231–272. Ontario: PMPH USA, 2006.
Son S, Kim S S, Son W S, Kim Y I, Kim Y D, Shin S H. Miniscrews versus surgical archwires for intermaxillary fixation in adults after orthognathic surgery. Korean J Orthod 2015; 45: 3–12.
Campos-Rodriguez F, Martinez-Alonso M, Sanchez-de-la-Torre M, Barbe F.. Long-term adherence to continuous positive airway pressure therapy in non-sleepy sleep apnea patients Sleep Med 2016; 17: 1–6.
Hoffstein V. Review of oral appliances for treatment of sleep-disordered breathing. Sleep Breath 2007; 11: 1–22.
Yu M S, Ibrahim B, Riley R W, Liu S Y. Maxillomandibular advancement and upper airway stimulation: extrapharyngeal surgery for obstructive sleep apnea. Clin Exp Otorhinolaryngol 2020; 13: 225–233.
Holty J E, Guilleminault C. Surgical options for the treatment of obstructive sleep apnea. Med Clin North Am 2010; 94: 479–515.
Verse T, Hörmann K. The surgical treatment of sleep-related upper airway obstruction. Dtsch Arztebl Int 2011; 108: 216–221.
Mashaqi S, Patel S I, Combs D et al. The hypoglossal nerve stimulation as a novel therapy for treating obstructive sleep apnea: a literature review. Int J Environ Res Public Health 2021; 18: 1642.
Strollo P J Jr Soose R J, Maurer J T et al. Upper-airway stimulation for obstructive sleep apnea. N Engl J Med 2014; 370: 139–149.
Li K K, Powell N B, Riley R W, Troell R J, Guilleminault C. Long-term results of maxillomandibular advancement surgery. Sleep Breath 2000; 4: 137–140.
AlGhanim N, Comondore V R, Fleetham J, Marra C A, Ayas N T. The economic impact of obstructive sleep apnea. Lung 2008; 186: 7–12.
Borsoi L, Armeni P, Donin G, Costa F, Ferini-Strambi L. The invisible costs of obstructive sleep apnea: systematic review and cost-of-illness analysis. PLos One 2022; DOI: 10.1371/journal.pone.0268677.
Utley D S, Shin E J, Clerk A A, Terris D J. A cost-effective and rational surgical approach to patients with snoring, upper airway resistance syndrome, or obstructive sleep apnea syndrome. Laryngoscope 1997; 107: 726–734.
Tan K B, Toh S T, Guilleminault C, Holty J E. A cost-effectiveness analysis of surgery for middle-aged men with severe obstructive sleep apnea intolerant of CPAP. J Clin Sleep Med 2015; 11: 525–535.
Blumen M B, Buchet I, Meulien P, Hausser Hauw C, Neveu H, Chabolle F. Complications and adverse effects of maxillomandibular advancement for the treatment of obstructive sleep apnea.. Otolaryngol Head Neck Surg 2009; 141: 591–597.
Zaghi S, Holty JE, Certal V et al. Maxillomandibular advancement for treatment of obstructive sleep apnea: a meta-analysis. JAMA Otolaryngol Head Neck Surg 2016; 142: 58–66.
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KHCC: conceptualisation, methodology, data curation, original draft preparation, figure preparation. SP: supervision, clinical expertise in orthodontics, critical revision of the manuscript. GG: technical expertise in surgical planning, figure preparation, critical revision. FR: supervision, surgical expertise, manuscript review and editing. All authors (KHCC, SP, GG, FR) reviewed and approved the final version of the manuscript.
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Chan, K., Patel, S., Grados, G. et al. Maxillomandibular advancement surgery for obstructive sleep apnoea patients: the current workflow from referral to recovery. Br Dent J 240, 334–341 (2026). https://doi.org/10.1038/s41415-025-9304-0
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DOI: https://doi.org/10.1038/s41415-025-9304-0


