Fig. 1 | British Journal of Cancer

Fig. 1

From: An integrative bioinformatics approach reveals coding and non-coding gene variants associated with gene expression profiles and outcome in breast cancer molecular subtypes

Fig. 1

Genes characterised by genetic variations in coding and non-coding regions in breast cancer. a A heatmap for recurrent variations in coding (green) and non-coding (orange) regions was generated for 930 tumours of the TCGA cohort. Clinicopathological features for each sample (i.e., ER, PGR, HER2 status and TNM stage) are shown. Each column represents an individual tumour and each row represents a gene. Different types of variations are highlighted with different colours. The right histogram displays the percentage of breast cancer harbouring sequence variants in the corresponding gene. Histograms showing the number of variations in b coding and c non-coding regions across all genes among all patients and each BC subgroup. Error bars represent 95% confidence intervals. *P < 0.05; **P < 0.01; *** P < 0.001

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