Table 2 Relationship between nuclear MED7 protein (IHC) and clinicopathological parameters of the Nottingham BC series
Clinicopathological Criteria | MED7 nuclear staining | χ2 (p-Value) | |
|---|---|---|---|
Low (%) | High (%) | ||
Age at diagnosis | |||
≤50 | 220 (48.6) | 233 (51.4) | 0.781 (0.381) |
>50 | 423 (51.1) | 404 (48.9) | |
Tumour size (cm) | |||
≤2.0 | 274 (44.1) | 348 (55.9) | 19.09 (<0.0001) |
>2.0 | 366 (56.3) | 284 (43.7) | |
Histological grade | |||
1 | 82 (39.8) | 124 (60.2) | 49.341 (<0.0001) |
2 | 174 (40.8) | 252 (59.2) | |
3 | 383 (60.2) | 253 (39.8) | |
Tubule formation | |||
1 | 26 (39.4) | 40 (60.6) | 15.589 (0.0004) |
2 | 185 (43.8) | 237 (56.2) | |
3 | 406 (54.6) | 338 (45.4) | |
Nuclear pleomorphism | |||
1 | 8 (26.7) | 22 (73.3) | 29.894 (<0.0001) |
2 | 195 (41.9) | 270 (58.1) | |
3 | 413 (56.2) | 322 (43.8) | |
Mitotic score | |||
1 | 164 (39.8) | 248 (60.2) | 43.005 (<0.0001) |
2 | 110 (44.4) | 138 (55.6) | |
3 | 343 (60.0) | 229 (40.0) | |
Tumour type | |||
Ductal | 551 (51.6) | 516 (48.4) | 20.575 (0.001) |
Lobulara | 41 (35.3) | 75 (64.7) | |
Medullary like | 22 (75.9) | 7 (24.1) | |
Special type | 22 (42.3) | 30 (57.7) | |
Lymph node stageb | |||
I | 398 (51.1) | 381 (48.9) | 1.853 (0.603) |
II | 191 (49.6) | 194 (50.4) | |
III | 50 (48.1) | 54 (51.9) | |
NPI | |||
Good prognostic group | 157 (40.6) | 230 (59.4) | 23.546 (<0.0001) |
Moderate prognostic group | 358 (53.1) | 316 (46.9) | |
Poor prognostic group | 125 (59.2) | 86 (40.8) | |
IHC-validated LVI | |||
Negative | 319 (47.5) | 352 (52.5) | 4.10 (0.04) |
Positive | 196 (54.1) | 166 (45.9) | |
