Fig. 6 | British Journal of Cancer

Fig. 6

From: The tyrosine-kinase inhibitor sunitinib targets vascular endothelial (VE)-cadherin: a marker of response to antitumoural treatment in metastatic renal cell carcinoma

Fig. 6

Proposed mechanisms of microenvironment-induced VE-cadherin structural modifications in kidney cancer. This working hypothesis was mainly built from our results obtained using in vitro EC cultures and VEGF as the major actor in angiogenesis.15, 20 The involvement of other cytokines in these processes cannot be excluded since we previously showed that TNFα induced sVE release19

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