Table 2 Prostate cancer risk by average fasting blood glucose and HbA1c level

From: Fasting blood glucose, glycaemic control and prostate cancer risk in the Finnish Randomized Study of Screening for Prostate Cancer

  

Prostate cancer risk

  

Overall

Gleason 6 or less

Gleason 7–10

Localised PCa

Metastatic

 

n of men/PCa cases

HR (95% CI)age-adjusted

HR (95% CI)multivar.-adjusteda

HR (95% CI)age-adjusted

HR (95% CI)multivar.-adjusteda

HR (95% CI)age-adjusted

HR (95% CI)multivar.-adjusteda

HR (95% CI)age-adjusted

HR (95% CI)multivar.-adjusteda

HR (95% CI)age-adjusted

HR (95% CI)multivar.-adjusteda

Fasting blood glucose level

 Normal

8,481/808

Ref

Ref

Ref

Ref

Ref

Ref

Ref

Ref

Ref

Ref

 Pre-diabetic

5,812/454

1.07 (0.99–1.23)

1.09 (0.95–1.26)

1.03 (0.84–1.27)

1.08 (0.95–1.26)

1.09 (0.89–1.34)

1.10 (0.90–1.36)

1.10 (0.94–1.27)

1.13 (0.97–1.31)

0.75 (0.43–1.31)

0.74 (0.42–1.30)

 Diabetic

3,567/401

1.36 (1.19–1.56)

1.52 (1.31–1.75)

1.26 (1.04–1.53)

1.48 (1.21–1.81)

1.38 (1–13–1.70)

1.46 (1.18–1.81)

1.39 (1.21–1.61)

1.57 (1.35–1.82)

0.99 (0.58–1.69)

0.94 (0.54–1.64)

HbA1c level

 Normal

3,978/431

Ref

Ref

Ref

Ref

Ref

Ref

Ref

Ref

Ref

Ref

 Pre-diabetic

4,342/338

1.13 (0.88–1.44)

1.15 (0.90–1.47)

1.07 (0.75–1.54)

1.11 (0.77–1.59)

1.17 (0.83–1.64)

1.18 (0.84–1.66)

1.13 (0.87–1.46)

1.16 (0.89–1.50)

1.05 (0.42–2.62)

1.08 (0.43–2.70)

 Diabetic

2,880/323

0.95 (0.73–1.23)

1.04 (0.80–1.35)

0.77 (0.53–1.13)

0.89 (0.60–1.31)

1.08 (0.75–1.53)

1.11 (0.77–1.59)

0.87 (0.67–1.15)

0.96 (0.73–1.26)

1.77 (0.73–4.30)

1.83 (0.74–4.52)

  1. Study cohort of 17,860 men from the Finnish Randomized Study of Screening for Prostate Cancer.
  2. aMultivariable-adjusted analyses adjusted with age, the FinRSPC study arm and use of antihypertensive drugs, statins, NSAIDs or aspirin
Back to article page