Table 1 Enzyme IC50 values of AZ304 against a panel of kinases

From: AZ304, a novel dual BRAF inhibitor, exerts anti-tumour effects in colorectal cancer independently of BRAF genetic status

Kinase

IC50 (nM)

BRAFV600E

38

BRAF

79

CRAF

68

p38

6

CSF1R

35

MAP3K7

6400

CSK

7050

IGF1R, EGFR, FGFR, CDK2, CDK4, JAK2, SRC

>10000

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