Fig. 1

a, b Volcano plot of differentially expressed (DE) genes between paraneoplastic cerebellar degeneration (PCD) related ovarian tumours and control ovarian tumours. In a, coloured in red, genes with p-value over 0.05 and logfold change absolute value over 1.1, in yellow, genes know to be DE between fresh-frozen and formalin-fixed paraffin embedded samples and in blue, CDR2L gene and related genes. In b, the coloured plot are the genes included in following Gene Ontology terms: GO:0021699 (red), GO:0042088 (purple), GO:0002448, GO:0032817 (green), and GO: 0050861 (blue). Most significant gene names are plotted. c Heatmap of the 1314 differentially expressed genes (rows) and 12 ovarian cancer samples related with an anti-Yo paraneoplastic syndrome (top panel, indicated in brown) and 733 ovarian cancer samples from public databases (top panel in blue). The heatmap to the left indicates z-scales expression values, and two columns to the right (base expr PCD and base expr non-PCD) express the log2 base mean expression of the 1314 genes in the ovarian cancer samples related to an anti-Yo paraneoplastic syndrome and the rest of the samples, respectively. The third column on the right highlights the 171 AIRE-related genes within the differentially expressed gene set. For AIRE-related genes with relatively high expression levels (larger than 50% quantile of all genes), the gene name is indicated as text labels