Table 1 Expression changes of genes associated with redox regulation and metastatic potential in MCF-7G1P3 cells
Gene symbol | Description | Fold change in MCF-7G1P3 cells | GO function | |
|---|---|---|---|---|
Gene array | qRT-PCR | |||
AKR1C2 | Aldo-keto reductase family 1 member C2 | 5.27 | 3.50 ± 0.77* | Aldo-keto reductase (NADP) |
AKR1B10 | Aldo-keto reductase family 1 member B10 | 4.45 | 5.15 ± 1.21* | Aldo-keto reductase (NADP) Oxidoreductase activity |
AKR1C3 | Aldo-keto reductase family 1 member C3 | 2.81 | 2.37 ± 0.43* | |
AKR1C4 | Aldo-keto reductase family 1 member C4 | 3.59 | 3.13 ± 0.46** | |
AXIN2 | Axin2 | 2.09 | ND | Epithelial-to-mesenchymal transition |
BMP4 | Bone morphogenetic protein 4 | 2.03 | ND | |
BMP5 | Bone morphogenetic protein 5 | 5.59 | 3.41 ± 0.72* | |
S100A4 | S100 calcium-binding protein A4 | 2.83 | ND | |
SNAI2 | Snail family transcriptional repressor 2 | 2.18 | 2.06 ± 0.23** | |
TGFBR2 | Transforming growth factor beta receptor 2 | 4.90 | 2.96 ± 0.25** | |
TGFBR3 | Transforming growth factor beta receptor 3 | 4.61 | ND | |
PAK1 | p21 (RAC1)-activated kinase 1 | 2.27 | 2.03 ± 0.02**** | Positive regulation of endothelial cell migration |
PRKD2 | Protein kinase D2 | 2.53 | ND | |
SEMA5A | Semaphorin 5A | 2.0 | ND | |
ANXA1 | Annexin A1 | 6.76 | 5.46 ± 1.21* | Regulation of response to wounding Regulation of wound healing |
LYN | LYN proto-oncogene, Src family tyrosine kinase | 2.51 | 2.44 ± 0.28* | |
NANOS3 | Nanos C2HC-type zinc finger 3 | 2.40 | ND | |
PLAU | Plasminogen activator, urokinase | 2.30 | ND | |
SERPINE2 | Serpin family E member 2 | 2.75 | 2.08 ± 0.05**** | |
GJA1 | Gap junction protein alpha 1 | 2.10 | 3.53 ± 0.72* | Regulation of response to wounding Regulation of wound healing |
CAV1 | Caveolin 1 | 4.52 | 4.75 ± 0.90* | |
NEBL | Nebulette | 0.48 | ND | Actin binding and remodelling |
LCP1 | Lymphocyte cytosolic protein 1 | 0.45 | ND | |
ABLIM1 | Actin-binding LIM protein 1 | 0.25 | ND | |
SCIN | Scinderin | 0.06 | 0.248 ± 0.009*** | |
