Table 3 Prognostic factor analysis of progression-free survival time

From: A randomised phase II study of second-line XELIRI regimen versus irinotecan monotherapy in advanced biliary tract cancer patients progressed on gemcitabine and cisplatin

Parameter

Median progression-free survival time (months) (95% CI)

P-value

XELIRI (n=30)

IRI (n=30)

Tumour site

 Gallbladder

2.3 (1.3, 3.3)

2.8 (1.9, 3.7)

0.689

 Non-gallbladder

4.9 (0.7, 9.1)

2.4 (1.8, 3.0)

0.032*

CA 19-9

 ≥400 IU/ml

2.3 (0.1, 5.0)

2.4 (0.5, 4.3)

0.341

 <400 IU/ml

4.3 (0.1, 9.6)

2.8 (2.4, 3.2)

0.022*

Age

 ≥60

2.6 (0.1, 7.0)

2.4 (1.8, 3.0)

0.079

 <60

2.0 (0.1, 5.7)

2.4 (1.7, 3.1)

0.124

Extent of disease

 Locally advanced

2.2 (0.9, 3.5)

2.4 (1.7, 3.1)

0.203

 Metastatic

3.7 (0.1, 7.6)

2.4 (2.2, 2.6)

0.053

  1. XELIRI irinotecan and capecitabine, IRI irinotecan, CI confidence interval.
  2. *P < 0.05