Fig. 1 | British Journal of Cancer

Fig. 1

From: Rare germline variants in DNA repair genes and the angiogenesis pathway predispose prostate cancer patients to develop metastatic disease

Fig. 1

Proportion of rare PTVs identified in the BROCA gene set. a Relative frequencies of Tier 1 mutations identified in the combined sample cohort by gene. In total, 22 rare protein truncating variants in BROCA panel genes were identified. b Proportion and relative frequencies of germline BROCA panel mutation carriers among metastatic cases. 18 BROCA PTVs, representing 11 unique genes, were identified in 17 patients from the aggressive cohort (12.2%). One individual was a carrier for 2 BROCA PTVs, both in NBN. c Proportion and relative frequencies of germline BROCA panel mutation carriers among non-aggressive cases. 4 BROCA PTVs, each in a unique gene, were identified in non-aggressive cases (2.8%)

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