Table 1 Clinicopathological data of the cholangiocarcinoma cohort with complete clinicopathological data and correlation to the high-level microsatellite instability status

From: Mismatch repair deficiency is a rare but putative therapeutically relevant finding in non-liver fluke associated cholangiocarcinoma

CCA cohort

Total Number (%)

MSI− Number (%)

MSI+ Number (%)

p-value

Number (%)

308 (100.0)

304 (98.7)

4 (1.3)

 

Age

 >Mediand

154 (50.0)

153 (49.7)

1 (0.3)

 

 <Median

154 (50.0)

151 (49.0)

3 (1.0)

0.37a

Sex

 Male

169 (54.9)

167 (54.2)

2 (0.6)

 

 Female

139 (45.1)

137 (44.5)

2 (0.6)

1.00b

CCA subgroups

 iCCA

159 (51.6)

157 (51.0)

2 (0.6)

 

 pCCA

106 (34.4)

104 (33.8)

2 (0.6)

 

 dCCA

43 (14.0)

43 (14.0)

0 (0.0)

0.65c

Histologye (predominant pattern)

 NOS

257 (83.4)

256 (83.1)

1 (0.3)

 

 Papillary

21 (6.8)

19 (6.2)

2 (0.6)

 

 Mucinous

2 (0.6)

2 (0.6)

0 (0.0)

 

 Intestinal

9 (2.9)

9 (2.9)

0 (0.0)

 

 Other

19 (6.2)

18 (5.8)

1 (0.3)

0.004 c

UICCf

 UICC 1

40 (13.0)

40 (13.0)

0 (0.0)

 

 UICC 2

70 (22.7)

70 (22.7)

0 (0.0)

 

 UICC 3

64 (20.8)

62 (20.1)

4 (1.3)

 

 UICC 4

81 (26.3)

79 (25.6)

0 (0.0)

 

 NA

53 (17.2)

53 (17.2)

0 (0.0)

0.36c

pT

 T1

75 (24.4)

73 (23.7)

2 (0.6)

 

 T2

118 (38.3)

117 (38.0)

1 (0.3)

 

 T3

91 (29.5)

90 (29.2)

1 (0.3)

 

 T4

24 (7.8)

24 (7.8)

0 (0.0)

0.65c

pN

 N0

116 (37.7)

116 (37.7)

0 (0.0)

 

 N1

138 (44.8)

134 (43.5)

4 (1.3)

 

 Nx

54 (17.5)

54 (17.5)

0 (0.0)

0.06b

M

 M0

298 (96.8)

294 (95.5)

4 (1.3)

 

 M1

10 (3.2)

10 (3.2)

0 (0.0)

0.71b

G

 G1

16 (5.2)

16 (5.2)

0 (0.0)

 

 G2

214 (69.5)

210 (68.2)

2 (0.6)

 

 G3

78 (25.3)

78 (25.3)

2 (0.6)

0.41c

L

 L0

132 (42.9)

132 (42.9)

0 (0.0)

 

 L1

176 (57.1)

172 (55.8)

4 (1.3)

0.08b

V

 V0

222 (72.1)

218 (70.8)

4 (1.3)

 

 V1

86 (27.9)

86 (27.9)

0 (0.0)

0.21b

Pn

 Pn0

244 (79.2)

240 (77.9)

4 (1.3)

 

 Pn1

64 (20.8)

64 (20.8)

0 (0.0)

0.30b

  1. NOS not otherwise specified, i.e., typical acinar, tubular, glandular pancreatobiliary histomorphology.
  2. Significant values are marked in bold. aMann–Whitney U-test.
  3. bFisher’s exact test
  4. cChi-square test.
  5. dMedian patients’ age was 63 years.
  6. eFor all tumours that showed a non-not otherwise specified (NOS) histomorphology the predominant pattern was assessed.
  7. fCases with pNx had no lymph nodes resected, therefore, UICC status could not be assessed
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