Fig. 1
From: Carbonic anhydrase IX is a pH-stat that sets an acidic tumour extracellular pH in vivo
Structural formula and NMR characteristics of the pHe probe ISUCA. a Structural formula of ISUCA, indicating the position of the H2 (red arrow), H4 AND H5 nuclei on the imidazole ring. b In vitro 1H MR spectra of ISUCA at different pH values in murine plasma at 37 °C, showing changes in chemical shift of the H2 peak with changes in pH. c pH calibration curve of the chemical shift of the ISUCA H2 peak in plasma at 37 °C, fitted to the Henderson–Hasselbalch equation
