Fig. 4
From: Carbonic anhydrase IX is a pH-stat that sets an acidic tumour extracellular pH in vivo
1H MRSI of tumour pHe reveals in vivo extracellular acidification by CAIX. a False coloured pHe maps of representative CA9 and EV tumours overlaid onto MR images encompassing the MRSI volume of interest, Scale bar: 10 mm. b pH values from the pHe maps of each tumour, with the medians. c Median tumour pHe values were lower for CA9 tumours (6.71, n = 8) than for EV tumours (6.86, n = 9; ***P = 0.001, Mann–Whitney test). d Cumulative histogram depicting pHe frequency distribution. CA9 tumours did not show any pHe value above 6.93, whereas 26.8% of the values for the EV tumours were above that.
