Fig. 2

Prognostic role of CD8 and PD-L1 expressions in TCGA cohort. a Scatter plot showing the correlation between CD8 mRNA expression and CD274 mRNA expression. b Kaplan Meier estimates for overall survival; patients were stratified according to CD8 (b) and CD274 (c) mRNA expression: high expression (CD8+/CD274+; in red) and low expression (CD8-/CD274−; in blue). d Kaplan–Meier estimates for overall survival; patients were stratified in two groups: a group with low expression of CD8A and high expression of CD274 mRNA (CD8A−/CD274+) and a group with the other patients. e Heat map of genes significantly differentially expressed between patients with low-mRNA CD8 and high-PD-L1 expression, and the other patients. The row side bar represents genes upregulated in the group of interest in blue and genes downregulated in yellow. f Pathway selected through an enrichment analysis performed on the downregulated genes using Enrichr with the KEGG 2016 database. g Pathway classification of the upregulated genes using Enrichr with the KEGG 2016 database. Cutoffs for low and high expressions were defined with the Cutoff Finder method. ^*p < 0.05; ^**p < 0.01; ^***p < 0.001; ^****p < 0.0001; ns not significant