Table 1 Summary of univariate and multivariate Cox models built on the predictive cohort data

From: Prognostic and predictive role of CD8 and PD-L1 determination in lung tumor tissue of patients under anti-PD-1 therapy

Multivariate Cox models

Variable

 

Univariate Cox models

Clinical model

Immunohistochemistry models

RNA sequencing models

Combined CD8/PD-L1 models

         

CD8

Sp142

 

CD8A

CD274

IHC

 

Bootstrapping

RNA-Seq

 

Bootstrapping

  

Hratio

95% IC

p

Adjusted p (FDR)

Hratio

95% IC

p

Hratio

95% IC

p

Hratio

95% IC

p

Hratio

95% IC

p

Hratio

95% IC

p

Hratio

95% IC

p

95%CI

p

Hratio

95% IC

p

95%CI

p

Sex

Female

1

   

1

  

1

  

1

  

1

  

1

  

1

    

1

    
 

Male

0.586

[0.331–1.04]

0.06

0.09

0.945

[0.489−1.826]

0.87

0.954

[0.486–1.874]

0.89

0.908

[0.454–1.815]

0.78

0.413

[0.152–1.124]

0.08

0.330

[0.114–0.954]

0.04

0.95

[0.481–1.859]

0.87

[0.413–2.602]

0.49

0.302

[0.105–0.868]

0.03

[0.037–1.555]

0.051

Age

Continuous

0.966

[0.941–0.992]

0.01

0.02

0.968

[0.942−0.994]

0.02

0.971

[0.943;0.999]

0.046

0.968

[0.941–0.996]

0.02

0.963

[0.926–1.002]

0.06

0.956

[0.916–0.998]

0.04

0.971

[0.943–1.000]

0.047

[0.929–1.005]

0.037

0.951

[0.910–0.994]

0.02

[0.838–1.004]

0.034

WHO performance status

0

1

   

1

  

1

  

1

  

1

  

1

  

1

    

1

    
 

1

0.986

[0.576–1.688]

0.96

0.96

0.879

[0.497−1.554]

0.66

0.830

[0.459–1.499]

0.536

0.875

[0.479–1.596]

0.66

0.705

[0.302–1.643]

0.42

0.850

[0.375–1.924]

0.70

0.837

[0.462–1.514]

0.56

[0.486–1.764]

0.44

0.665

[0.291–1.524]

0.34

[0.204–2.715]

0.40

 

2

9.045

[3.373–24.25]

1.2E−5

1.1E−4

7.289

[2.614−20.323]

0.0001

5.064

[1.667–15.382]

0.004

6.980

[2.287–21.301]

0.0006

4.588

[1.137–18.515]

0.03

5.130

[1.283–20.521]

0.02

5.071

[1.657–15.522]

0.004

[2.189–42.804]

0.005

3.985

[0.993–15.988]

0.051

–

–

Histology

Nonsquamous cell

1

   

1

  

1

  

1

  

1

  

1

  

1

    

1

    
 

Squamous cell

0.676

[0.405–1.127]

0.13

0.18

0.812

[0.455−1.449]

0.48

0.913

[0.507–1.644]

0.76

0.823

[0.449–1.507]

0.53

1.050

[0.454–2.429]

0.91

1.256

[0.503–3.138]

0.63

0.885

[0.487–1.606]

0.69

[0.365–1.934]

0.36

1.301

[0.536–3.156]

0.56

[0.120–5.294]

0.34

CD8 expression

Low

1

-

1

-

-

-

1

-

 

High

0.375

[0.218−0.646]

0.0002

0.0009

 

0.413

[0.234−0.732]

0.002

   

0.437

[0.243−0.785]

0.006

[0.176−0.840]

0.008

 

PD-L1 expression (Sp142)

Low

1

-

-

1

-

-

1

-

 

High

0.764

[0.452−1.292]

0.31

0.35

  

0.642

[0.372−1.109]

0.11

  

0.759

[0.436−1.320]

0.33

[0.366−2.341]

0.26

 

CD8 expression (CD8A)

Low

1

78

-

-

1

-

-

1

 

High

0.14

[0.033−0.594]

0.002

0.006

   

0.115

[0.025−0.532]

0.006

  

0.163

[0.033−0.798]

0.03

[0.001−0.934]

0.048

PD-L1 expression (CD274)

Low

1

-

-

-

-

1

-

1

 

High

0.332

[0.140−0.788]

0.009

0.02

    

0.225

[0.079−0.638]

0.005

 

0.366

[0.127−1.051]

0.06

[0.069−1.134]

0.07

Statistics

AIC

-

460

401

408

176

178

402

173

Harrell’s C-statistic

0.66

0.76

0.70

0.84

0.86

0.78

0.90

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