Fig. 3
a Individual protein loading in principal component 1 and 2 of 1877 quantified proteins across the 32 melanoma tissues with indication of proteins with highest positive loading in component 1 and highest negative loading in component 2; NGAL, neutrophil gelatinase-associated lipocalin; DEF3, neutrophil defensin 3; PERM, myeloperoxidase; CATG, cathepsin G; LYSC, lysozyme C; TRFL, lactotransferrin; CAP7, azurocidin; GPNMB, transmembrane glycoprotein NMB; GP143, G-protein coupled receptor 143. b Hierarchical clustering of melanoma tissue samples based on significantly changing proteins from PCA component 2 (q value < 0.1 and fold change >2-fold). c 2D projection of PCA from SWATH analysis of melanoma tissues with indication of predicted MEKi sensitive (light blue) and MEKi resistant (orange) phenotype
