Table 1 Baseline demographics and patient characteristics

From: Target-based therapeutic matching of phase I trials in patients with metastatic breast cancer in a tertiary referral centre

Baseline characteristics

Matched (N = 59)

Non-matched (N = 54)

Age, mean (SD), years

51.1 (12.7)

51.5 (10.1)

ECOG PS baseline, n (%)

  0

36 (61)

33 (61)

  1

23 (39)

21 (39)

RMH prognostic score, n (%)

  0–1

33 (56)

34 (63)

  2–3

26 (44)

20 (37)

Histologic subtype, n (%)

  ER+/HER2−

27 (47)

24 (47)

  TNBC

21 (35)

17 (32)

  HER2+/ER+

8 (13)

7 (12)

  HER2+/ER−

3 (5)

6 (11)

Number sites of disease

  Median (range)

3 (1–7)

3 (1–6)

Sites of disease, n (%)

  Nodal

41 (68)

29 (55)

  Locoregional

29 (48)

37 (70)

  Bone

35 (58)

25 (47)

  Lung

26 (43)

18 (34)

  Liver

18 (30)

20 (38)

  CNS

0 (0)

2 (4)

Lines of prior therapy, median (range)

  Chemotherapy

3 (0–8)

3 (0–8)

  Endocrine therapya

2 (1–4)

2 (1–4)

  HER2-directed therapyb

2 (1–4)

2 (1–4)

  1. CNS Central nervous system, ECOG Eastern Co-operative Oncology Group, ER oestrogen receptor, HER2 human epidermal growth factor receptor 2, or erbB-2, PS performance status, RMH Royal Marsden Hospital, SD standard deviation, TNBC triple-negative breast cancer
  2. aOnly participants with ER+ MBC
  3. bOnly participants with HER2+ MBC