Fig. 1 | British Journal of Cancer

Fig. 1

From: Combinations of BRAF inhibitor and anti-PD-1/PD-L1 antibody improve survival and tumour immunity in an immunocompetent model of orthotopic murine anaplastic thyroid cancer

Fig. 1

Treatment of immunocompetent mice with orthotopic ATC (TBP-3743) with PLX4720 and/or anti-PD-1/anti-PD-L1 as single agents and combination therapy; experiment was repeated twice. a Experimental design, treatment randomisation, and schedule. b Combination therapy for 1 week led to 61.3% (PLX4720 + anti-PD-1) and 63.7% (PLX4720 + anti-PD-L1) tumour growth inhibition vs. controls (p < 0.01). c Combination-treated mice survived for a median of 28 ± 2.5 days (PLX4720 + anti-PD-1) and 28 ± 0.9 days (PLX4720 + anti-PD-L1), both significantly longer than controls (p < 0.001)

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