Fig. 3 | British Journal of Cancer

Fig. 3

From: Combinations of BRAF inhibitor and anti-PD-1/PD-L1 antibody improve survival and tumour immunity in an immunocompetent model of orthotopic murine anaplastic thyroid cancer

Fig. 3

a One week of combination therapy led to a dramatic increase in CD8+ cytotoxic T cells, granzyme B staining, and FoxP3+ T cells. b Milliplex cytokine analysis showed complex changes after treatment for 1 and 3 weeks; IFNγ increased during maximal response and decreased during tumour regrowth compared to control. c All mice treated with PLX4720 singly or in combination had a dramatic increase NK cells (representative samples shown using NK1.1 antibody). N = 4 mice per group, repeated twice

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