Fig. 3
From: Early immune modulation by single-agent trastuzumab as a marker of trastuzumab benefit
Expression of MHC-II in TRUP tumours. a Representative IHC images of MHC-II expression in FFPE tumour biopsies of the TRUP cohort. Scale bars: 50 μm. b Change in M1 macrophage fraction as evaluated using the CIBERSORT tool on treatment with trastuzumab in cases of the TRUP cohort according to response to trastuzumab-based chemotherapy, as evaluated at surgery. Fold-change in C+K+ tumours is also shown. p-values by unpaired t-test. c Correlation between changes in MHC-II and M1 (fold-change) induced by trastuzumab in all cases of the TRUP cohort. Spearman coefficients and relative p-values are shown
