Fig. 1 | British Journal of Cancer

Fig. 1

From: (Pro)renin receptor promotes colorectal cancer through the Wnt/beta-catenin signalling pathway despite constitutive pathway component mutations

Fig. 1

(P)RR is highly expressed in human CRC tissues. a Representative image of (P)RR staining by IHC in colorectal tissues, which contains both cancer and normal tissues. Yellow arrow: cancer tissue with messy and irregular gland structure. Black arrow: normal tissue with regular gland structure. b, c Representative IHC images of (P)RR staining in normal (b) and cancer (c) tissues with higher magnification. d Western blotting analysis of (P)RR expression levels in cancer and matched normal tissues (n = 5). Data are presented as mean ± SEM. e Representative IHC images of (P)RR staining in CRC tissues with different differentiated grades. f Comparison of percentages of patients showing strong, middle or weak (P)RR expression in groups with different CRC grades (n = 17, 30 and 13 in Grade 1, 2 and 3). *P < 0.05, ***P < 0.001

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