Table 2 Association between CTC presence and grade, previous treatment and sites of metastases

From: Circulating tumour cells and their association with bone metastases in patients with neuroendocrine tumours

 

pNETs

p

Midgut NETs

p

 

(n=119)

 

(n=121)

 
 

CTC=0

CTC1

 

CTC=0

CTC1

 

Tumour grade (%)

  

0.0193

  

0.0009

 G1

74

26

 

55

45

 

 G2

63

37

 

45

55

 

 G3

55

45

 

29

71

 

 Previous treatment (n)

  

0.134

  

0.1418

 Treatment naive

23

12

 

19

11

 

 On SSAs

14

7

 

22

28

 

 Previous anti-cancer treatments*

39

23

 

16

23

 

Lung metastases ( n )

  

0.31

  

0.33

 Yes

5

1

 

5

9

 

 No

71

42

 

54

53

 

Peritoneal metastases ( n )

  

0.12

  

0.80

 Yes

13

3

 

31

34

 

 No

63

40

 

28

28

 

Bone metastases ( n )

  

 < 0.0001

  

0.003

 Yes

7

20

 

10

26

 

 No

69

23

 

49

36

 

Lymph node metastases ( n )

  

0.1861

  

0.4162

 Yes

40

28

 

45

51

 

 No

36

15

 

14

11

 
  1. *Treatments include chemotherapy, radionuclide therapy, targeted therapy, interferon and liver-directed therapy.