Table 4 Risk of incident pancreatic cancer by family history of breast or colorectal cancer, stratified by Ashkenazi Jewish ancestry

	Family history of breast cancer		P _interaction ^b	Family history of colorectal cancer		P _interaction ^b
	Absent	Present	P _interaction ^b	Absent	Present	P _interaction ^b
Ashkenazi Jewish
No. of cases	30	15		36	17
Person-years	50,651	10,172		62,891	13,042
Age-adjusted HR (95% CI)	1 (referent)	2.57 (1.40–4.73)	0.04	1 (referent)	1.92 (1.06–3.49)	0.12
Multivariable HR (95% CI)^a	1 (referent)	2.61 (1.41–4.82)	0.04	1 (referent)	1.92 (1.05–3.49)	0.13
Non-Ashkenazi Jewish
No. of cases	137	28		171	35
Person-years	281,124	47,303		355,058	59,442
Age-adjusted HR (95% CI)	1 (referent)	1.22 (0.81–1.82)		1 (referent)	1.10 (0.76–1.59)
Multivariable HR (95% CI)^a	1 (referent)	1.22 (0.82–1.83)		1 (referent)	1.11 (0.77–1.60)

CI Confidence interval, HR hazard ratio, MET metabolic equivalent of task
^aThe Cox proportional hazards regression models were adjusted for age (continuous), race (white, black, other, or unknown), calendar year of questionnaire cycle (continuous), smoking in pack-years (never, 0.1–4.9, 5–19.9, 20–39.9, or ≥40), history of diabetes (yes/no), body mass index (<25, 25–29.9, 30–34.9, or ≥35 kg/m²), physical activity (MET-hours/week in quintiles), alcohol intake (0, 0.1–4.9, 5–14.9, 15–29.9, or ≥30 g/day), and regular multivitamin use (yes/no)
^bP_interaction was calculated using the Wald test for the cross-product of cancer family history (yes/no) and Ashkenazi Jewish ancestry (yes/no)

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