Table 5 Risk of incident pancreatic cancer by family history of breast or colorectal cancer, stratified by covariates
From: Family history of cancer, Ashkenazi Jewish ancestry, and pancreatic cancer risk
Family history of breast cancer | P interaction b | Family history of colorectal cancer | P interaction b | |||
|---|---|---|---|---|---|---|
Absent | Present | Absent | Present | |||
Never smoker | 0.87 | 0.05 | ||||
No. of cases | 78 | 20 | 131 | 37 | ||
Person-years | 206,719 | 36,090 | 471,348 | 69,793 | ||
Multivariable HR (95% CI)a | 1 (referent) | 1.39 (0.84–2.28) | 1 (referent) | 1.56 (1.07–2.26) | ||
Ever smoker | ||||||
No. of cases | 115 | 24 | 234 | 39 | ||
Person-years | 213,983 | 37,221 | 513,042 | 77,773 | ||
Multivariable HR (95% CI)a | 1.10 (0.81–1.50) | 1.45 (0.90–2.32) | 1.35 (1.08–1.68) | 1.27 (0.88–1.82) | ||
Body mass index < 25 kg/m2 | 0.77 | 0.87 | ||||
No. of cases | 85 | 20 | 159 | 35 | ||
Person-years | 192,917 | 34,310 | 450,009 | 66,556 | ||
Multivariable HR (95% CI)a | 1 (referent) | 1.32 (0.81–2.17) | 1 (referent) | 1.24 (0.86–1.80) | ||
Body mass index ≥ 25 kg/m2 | ||||||
No. of cases | 110 | 26 | 213 | 45 | ||
Person-years | 242,735 | 41,707 | 567,445 | 85,899 | ||
Multivariable HR (95% CI)a | 1.00 (0.74–1.34) | 1.46 (0.93–2.30) | 0.98 (0.79–1.22) | 1.17 (0.84–1.64) | ||
No diabetes | 0.61 | 0.75 | ||||
No. of cases | 157 | 36 | 304 | 64 | ||
Person-years | 390,110 | 68,593 | 938,865 | 138,689 | ||
Multivariable HR (95% CI)a | 1 (referent) | 1.34 (0.93–1.94) | 1 (referent) | 1.19 (0.90–1.56) | ||
Diabetes | ||||||
No. of cases | 38 | 10 | 68 | 16 | ||
Person-years | 45,661 | 7445 | 82,229 | 14,043 | ||
Multivariable HR (95% CI)a | 1.87 (1.29–2.72) | 3.09 (1.60–5.98) | 1.86 (1.41–2.44) | 2.44 (1.45–4.09) | ||
