Fig. 2

Examples from CD3 and CD8 stainings showing part of tumour and invasive margins from synchronous microsatellite stable - microsatellite unstable (MSS-MSI), MSS-MSS and MSI-MSI tumour pairs. a–d MSS-MSI tumour pair: MSS c440-1 with IS3 and MSI c440-2 with IS4 (a and b are CD3 and CD8 stainings from c440-1 and c and d CD3 and CD8 stainings from c440-2, respectively). e–h MSS-MSS tumour pair: s404-1 with IS4 and s404-2 with IS1 (e and f are CD3 and CD8 stainings from s404-1 and g and h CD3 and CD8 stainings from s404-2, respectively). i–l MSI-MSI tumour pair: sync 4-1 with IS0 and sync 4-2 with IS4 (i and j are CD3 and CD8 stainings from sync 4-1 and k and l CD3 and CD8 stainings from sync 4-2, respectively). Photos were captured with a ×20 magnification